LDN-192960-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Agonists • Screening Libraries www.MedChemE LDN-192960 Cat. No.: HY-13455 CAS No.: 184582-62-5 分⼦式: C₁₈H₂₀N₂O₂S 分⼦量: 328.43 作⽤靶点: Haspin Kinase; DYRK 作⽤通路: Cell Cycle/DNA Damage; Protein Tyrosine Kinase/RTK 储存⽅式: Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month BIOLOGICAL ACTIVITY ⽣物活性 LDN-192960 是 Haspin 和 DYRK2 的双重抑制剂，IC50 值分别为 10 nM 和 48 nM。 IC50 Target IC50: 10 nM (Haspin); 48 nM (DYRK2) [1] 体外研究 LDN-192960 (10 μM) is selective and inhibits ten of the other kinases by ≥90%, with only five being potently inhibited (IC5050=0.21 μM), DYRK1A (IC50= 0.10 μM), DYRK2 (IC50=2 nM), DYRK3 (IC50=19 nM) and PIM1 (IC50=0.72 μM) [1]. REFERENCES [1]. Cuny GD, et al. Structure-activity relationship study of acridine analogs as haspin and DYRK2 kinase inhibitors. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3491-4. McePdfHeight Caution: Product has not been fully validated for medical applications.