AZD1979-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Agonists • Screening Libraries www.MedChemE AZD1979 Cat. No.: HY-U00257 CAS No.: 1254035-84-1 分⼦式: C₂₅H₂₆N₄O₅ 分⼦量: 462.5 作⽤靶点: MCHR1 (GPR24) 作⽤通路: GPCR/G Protein; Neuronal Signaling 储存⽅式: Please store the product under the recommended conditions in the COA. BIOLOGICAL ACTIVITY ⽣物活性 AZD1979 是⼀个 Melanin-concentrating hormone receptor 1 (MCHr1) 拮抗剂, 其 IC50 值约为 12 nM。 IC50 Target IC50: ~12 nM (MCHr1) [1] 体内研究 In DIO mice, initial AZD1979-mediate body weight loss is driven by decreasing food intake, but an additional component of preserving energy expenditure is apparent in pair-feeding and indirect calorimetry studies. AZD1979 also dose-dependently reduces body weight in dogs [1]. PROTOCOL Animal Three weeks after the light-dark cycle have been reversed, all mice are sham dosed by p.o. gavage for 6 Administration [1] days to habituate the animals to the procedure, randomized into experimental groups base on average body weights and dosed p.o. with AZD1979 (20, 40 or 60 μmol/kg twice daily at 8:00 h and 15:00 h) or vehicle (0.5% HPMC, 0.1% Tween twice daily) for 21 days (n=6 per group). Three mice per group are then dosed once more with the respective doses of AZD1979 (20, 40 or 60 μmol/kg p.o.) and kil