L-Eflornithine-L-DFMO-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Agonists • Screening Libraries www.MedChemE L-Eflornithine Cat. No.: HY-B0744C CAS No.: 66640-93-5 Synonyms: L-DFMO; L-RMI71782; L-α-difluoromethylornithine 分⼦式: C₆H₁₂F₂N₂O₂ 分⼦量: 182.17 作⽤靶点: Others 作⽤通路: Others 储存⽅式: Please store the product under the recommended conditions in the COA. BIOLOGICAL ACTIVITY ⽣物活性 L-Eflornithine (L-DFMO) 是 Eflornithine 的对映异构体。L-Eflornithine 是⼀种不可逆的鸟氨酸脱羧酶 ( ornithine decarboxylase, ODC) 抑制剂，KD 为 1.3±0.3 μM，Kinact 为 0.15±0.03 min-1 [1]。 IC50 Target KD:1.3±0.3 µM (Ornithine decarboxylase, ODC) [1] 体外研究 Eflornithine (D/L-DFMO) is an inhibitor of ODC, the first enzyme in eukaryotic polyamine biosynthesis. Both enantiomers of Eflornithine (DFMO) irreversibly inactivate ODC. Both Eflornithine enantiomers (L-Eflornithine and D-Eflornithine) suppress ODC activity in a time- and concentration-dependent manner. The inhibitor dissociation constant (KD) values for the formation of enzyme-inhibitor complexes are 28.3±3.4, 1.3±0.3 and 2.2±0.4 µM respectively for D-Eflornithine, L-Eflornithine and Eflornithine. The inhibitor inactivation constants (Kinact) for the irreversible step were 0.25±0.03, 0.15±0.03 and 0.15±0.03 min-1 respectively for D- Eflornithine