CDDO-dhTFEA-RTA-dh404-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Agonists • Screening Libraries www.MedChemE CDDO-dhTFEA Cat. No.: HY-112671 CAS No.: 1191265-33-4 Synonyms: RTA dh404 分⼦式: C₃₃H₄₅F₃N₂O₃ 分⼦量: 574.72 作⽤靶点: Keap1-Nrf2; NF-κB 作⽤通路: NF-κB 储存⽅式: Please store the product under the recommended conditions in the COA. BIOLOGICAL ACTIVITY ⽣物活性 CDDO-dhTFEA (RTA dh404) 是⼀种合成的齐墩果烷三萜化合物，有效激活 Nrf2 并抑制促炎转录因⼦ NF- κ B。 CDDO-dhTFEA 可以恢复⾼⾎压 (MAP)，增加 Nrf2 及其靶基因的表达，减弱 NF- κB 的活化和转化⽣长因 ⼦- β 途径，并减少慢性肾病 (CKD) ⼤⿏的肾⼩球硬化，间质纤维化和炎症。 IC50 Target NF-κB Nrf2 REFERENCES [1]. Aminzadeh MA, et al. The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores endothelial function impaired by reduced Nrf2 activity in chronic kidney disease. Redox Biol. 2013 Oct 31;1:527-31. [2]. Aminzadeh MA, et al. The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores Nrf2 activity and attenuates oxidative stress, inflammation, and fibrosis in rats with chronic kidney disease. Xenobiotica. 2014 Jun;44(6):570-8. McePdfHeight Caution: Product has not been fully validated for medical applications.