Duocarmycin-A-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Agonists • Screening Libraries www.MedChemE Duocarmycin A Cat. No.: HY-12455 CAS No.: 118292-34-5 分⼦式: C₂₆H₂₅N₃O₈ 分⼦量: 507.49 作⽤靶点: ADC Cytotoxin; Apoptosis; Caspase 作⽤通路: Antibody-drug Conjugate/ADC Related; Apoptosis 储存⽅式: Please store the product under the recommended conditions in the COA. BIOLOGICAL ACTIVITY ⽣物活性 Duocarmycin A 是众所周知的抗肿瘤抗⽣素之⼀，可有效地使 DNA 中富含 AT 的序列 3 末端的腺嘌呤 N3 烷基 化。Duocarmycin A 作为⼀种化学治疗剂，通常导致 HLC-2 细胞凋亡，包括染⾊质浓缩，DNA 直⽅图模式中 的亚 G1 积累，以及procaspase-3 和 9 ⽔平的降低。 IC50 Target Procaspase-3 Caspase-9 REFERENCES [1]. Hirota M, et al. Distamycin A enhances the cytotoxicity of duocarmycin A and suppresses duocarmycin A-induced apoptosis in human lung carcinoma cells. Int J Biochem Cell Biol. 2007;39(5):988-96. McePdfHeight Caution: Product has not been fully validated for medical applications. For research use only. Tel: 400-820-3792; 021 Fax: 021 E-mail: tech@MedChemE 1/1 Master of S