AZD1390-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Agonists • Screening Libraries www.MedChemE AZD1390 Cat. No.: HY-109566 CAS No.: 2089288-03-7 分⼦式: C₂₇H₃₂FN₅O₂ 分⼦量: 477.57 作⽤靶点: ATM/ATR 作⽤通路: Cell Cycle/DNA Damage; PI3K/Akt/mTOR 储存⽅式: Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month 溶解性数据 体外实验 DMSO : 25 mg/mL (52.35 mM; Need ultrasonic and warming) Mass Solvent 1 mg 5 mg 10 mg Concentration 制备储备液 1 mM 2.0939 mL 10.4697 mL 20.9393 mL 5 mM 0.4188 mL 2.0939 mL 4.1879 mL 10 mM 0.2094 mL 1.0470 mL 2.0939 mL 请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存⽅式和期限。 BIOLOGICAL ACTIVITY ⽣物活性 AZD1390 是⼀种 ATM 抑制剂。 IC50 Target ATM 体内研究 Median survival of mice treated with AZD1390 and radiation are significantly longer than untreated control mice (p=0.001). No overt signs of treatment toxicity are observed with smal