Belvarafenib-TFA-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Agonists • Screening Libraries www.MedChemE Belvarafenib TFA Cat. No.: HY-109080A 分⼦式: C₂₅H₁₇ClF₄N₆O₃S 分⼦量: 592.95 作⽤靶点: Raf 作⽤通路: MAPK/ERK Pathway 储存⽅式: Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month BIOLOGICAL ACTIVITY ⽣物活性 Belvarafenib (TFA) 是⼀种有效的，⼴泛的迅速加速纤维⾁瘤激酶 (RAF) 的抑制剂，其对 B-RAF，B-RAFv600E 和C-RAF 的 IC50 值分别为 56 nM, 7 nM 和 5 nM。 IC50 Target IC50: 56 nM(B-RAF), 7 nM(B-RAFv600E), 5 nM(C-RAF) [1]. 体外研究 Belvarafenib (Example 116) is a potent and pan RAF inhibitor with antineoplastic activity. The IC50 values of Belvarafenib are 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively. It also shows high inhibitory activity for FMS, DDR1 and DDR2 kinases, with IC50s of 10 nM, 23 nM and 44 nM, respectively [1]. REFERENCES [1]. WO 2013/100632 A1. McePdfHeight Caution: Product has not been fully validated for medical applications. For research use only. Tel: 400-820-3792; 021 Fax: 021 E-mai