AZD3988-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Agonists • Screening Libraries www.MedChemE AZD3988 Cat. No.: HY-50861 CAS No.: 892489-52-0 分⼦式: C₂₃H₂₂F₂N₄O₄ 分⼦量: 456.44 作⽤靶点: Acyltransferase 作⽤通路: Metabolic Enzyme/Protease 储存⽅式: Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month BIOLOGICAL ACTIVITY ⽣物活性 AZD3988 是⼀种⼆酰⽢油酰基转移酶-1 (DGAT-1) 抑制剂，在⼈，⼤⿏，⼩⿏中的 IC50 值分别为 6 nM、5 nM、11 nM [1]。 IC50 Target IC50: 6 nM (h DGAT-1), 5 nM (Rat DGAT-1), 11 nM (Mouse DGAT-1) [1] REFERENCES [1]. McCoull W, et al. Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes. Bioorg Med Chem Lett. 2012 Jun 15;22(12):3873-8. McePdfHeight Caution: Product has not been fully validated for medical applications. For research use only. Tel: 400-820-3792; 021 Fax: 021 E-mail: tech@MedChemE 1/1 Master of Small Molecules —