AT-1002-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Agonists • Screening Libraries www.MedChemE AT-1002 Cat. No.: HY-114426 CAS No.: 835872-35-0 分⼦式: C₃₂H₅₃N₉O₇S 分⼦量: 707.88 作⽤靶点: Gap Junction Protein 作⽤通路: Cytoskeleton 储存⽅式: Please store the product under the recommended conditions in the COA. BIOLOGICAL ACTIVITY ⽣物活性 AT-1002 是⼀种 6 聚体合成肽 [1]，是⼀种紧密连接 (junction) 的调节剂和吸收增强剂 [2]。 体外研究 AT-1002, a 6-mer synthetic peptide, belongs to an emerging novel class of compounds that reversibly increase paracellular transport of molecules across the epithelial barrier. AT-1002 can undergo Cys-Cys dimerization [1]. Undifferentiated Caco-2 cells are treated with AT-1002 (0 to 5 mg/mL, 3 or 24 hours) and viability is assessed by measuring cellular ATP content. Treatment with AT-1002 for up to 3 h does not affect cell viability at any concentration. In particular, the viability of Caco-2 cells is not affected by 5 mg/mL AT-1002. AT-1002 reduces cell viability after 24 h at concentrations of 2.5 mg/mL and higher. However, the cells remain viable after 24 h if the cells are washed after exposure to AT-1002 for 3 h indicating that AT-1002 does not irreversibly damage cells [2]. Cell Viability