GDC-0927-Racemate-SRN-927-Racemate-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Screening Libraries • Proteins www.MedChemE GDC-0927 Racemate Cat. No.: HY-111484A CAS No.: 1443983-36-5 Synonyms: SRN-927 Racemate 分⼦式: C₂₈H₂₈FNO₄ 分⼦量: 461.52 作⽤靶点: Estrogen Receptor/ERR 作⽤通路: Others 储存⽅式: Please store the product under the recommended conditions in the Certificate of Analysis. BIOLOGICAL ACTIVITY ⽣物活性 GDC-0927 Racemate (SRN-927 Racemate) 是雌激素受体 (estrogen receptor) 的降解剂，能够有效抑制 ER- α 的活性，IC50 值为 0.2 nM，可⽤于雌激素受体有关的疾病。 IC50 Target IC50: 0.2 nM (ER-α) [1] 体外研究 GDC-0927 Racemate (Example 1) is a degrader of estrogen receptor, potently inhibits ER-α activity, with an IC50 of 0.2 nM, and is used in the research of ER-related diseases. GDC-0927 Racemate reduces the viability of MCF7 cells with an IC50 of 0.21 nM [1]. REFERENCES [1]. Mehmet Kahraman, et al. Estrogen receptor modulator and uses thereof. WO2014205138A1. McePdfHeight Caution: Product has not been fully validated for medical applications. For research use only. Tel: 400-820