diABZI-STING-agonist-1-Tautomerism-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Screening Libraries • Proteins www.MedChemE diABZI STING agonist-1 (Tautomerism) Cat. No.: HY-112921 CAS No.: 2138498-18-5 分⼦式: C₄₂H₅₁N₁₃O₇ 分⼦量: 849.94 作⽤靶点: STING 作⽤通路: Immunology/Inflammation 储存⽅式: Please store the product under the recommended conditions in the Certificate of Analysis. BIOLOGICAL ACTIVITY ⽣物活性 diABZI STING agonist-1 Tautomerism (compound 3) 是⼀个选择性的⼲扰素基因刺激受体 (STING) 的激动剂 ，其在⼈和⼩⿏中的 EC50 值分别为 130 nM 和 186 nM。。 IC50 Target EC50: 130 nM (human STNG in PBMCs) [1]. 体外研究 diABZI STING agonist-1 (Tautomerism) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively. At a concentration of 1 μM, diABZI STING agonist-1 (compound 3) demonstrates high selectivity against more than 350 kinases tested [1]. 体内研究 diABZI STING agonist-1 (Tautomerism) (subcutaneous injection; 2.5 mg/kg) induces STING-dependent activation of type-I interferon and pro-inflammatory cytokines in vivo [1].diABZI STING agonist-1 (Tautomerism) (intravenous injection; 3 mg/kg) exhibits systemic exposure with a half-life of 1.4 h and achieves systemic concentrations greater than the half-maximal effective concentration (EC50) for mouse STING (200 ng/ml) [1].diABZI