AB-680-ammonium-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Screening Libraries • Proteins www.MedChemE AB-680 ammonium Cat. No.: HY-125286A 分⼦式: C₂₀H₃₀ClFN₆O₉P₂ 分⼦量: 614.89 作⽤靶点: CD73 作⽤通路: Immunology/Inflammation 储存⽅式: Please store the product under the recommended conditions in the Certificate of Analysis. BIOLOGICAL ACTIVITY ⽣物活性 AB-680 ammonium 是⼀种有效、可逆、选择性的 CD73 (胞外核苷酸酶) 抑制剂，对 hCD73 的 Ki 值为 4.9 pM，对其选择性是对相关胞外核苷酸酶 CD39 的 10000 多倍。具有抗肿瘤活性 [1]。 IC50 Target Ki: 4.9 pM (hCD73) [1] 体外研究 AB-680 ammonium inhibits soluble hCD73 with an IC50 of 0.043 nM, also inhibits hCD73 in CHO cells, suppresses CD73 in human, mouse CD8+ T Cells and hPBMC, with IC50s of 0.070, 0.008, 0.66 and 0.011 nM, respectively [1]. 客户使⽤本产品发表的科研⽂献 • J Immunother Cancer. 2021 Jul;9(7):e002503. • Cancer Immunol Res. 2022 Nov 21;CIR-22-0260. • Front Immunol. 2022, 13: Online ahead of print. • Front Immunol. 04 October 2022. • Research Square Preprint. 2021 Mar. See more customer validations on www.MedChemE REFERENCES [1]. Lawson KV, et al. Discovery and Characterization of AB680, a Potent and Selective Small-Molecule CD73 Inhibitor for Cancer Immunotherapy. 1/2 Master of Bioactive Molecules — 您⾝边的抑制剂⼤师