BGT226-NVP-BGT226-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Screening Libraries • Proteins www.MedChemE BGT226 Cat. No.: HY-13334A CAS No.: 915020-55-2 Synonyms: NVP-BGT226 分⼦式: C₂₈H₂₅F₃N₆O₂ 分⼦量: 534.53 作⽤靶点: PI3K; mTOR; Autophagy 作⽤通路: PI3K/Akt/mTOR; Autophagy 储存⽅式: Please store the product under the recommended conditions in the Certificate of Analysis. BIOLOGICAL ACTIVITY ⽣物活性 BGT226 (NVP-BGT226) 是⼀种 PI3K (针对 PI3K α，PI3K β，PI3K γ 的 IC50分别是4 nM，63 nM，38 nM ) /mTOR 双抑制剂，对⼈头颈癌细胞具有较强的⽣长抑制活性 [1] [2]。 IC50 Target PI3Kα PI3Kβ PI3Kγ mTOR 4 nM (IC50) 63 nM (IC50) 38 nM (IC50) Autophagy 体外研究 BGT226 shows significant growth inhibition or signal blockage profiles compared with LY294002 and Rapamycin. BGT226 (10-10000 nM) inhibits FaDu and OECM1 cells growth with IC50s of 23.1±7.4 and 12.5±5.1 nM, respectively [2]. The expression levels of p-mTOR Ser2481 are decreased in BGT226-treated cell lines (200 nM; 24 hours) and both p-AKT Ser473 and p-mTOR Ser2448 are also decreased in BGT226-treated cell lines [2]. Cell Viability Assay [2] Cell Line: FaDu cells; OECM1 cells Concentration: 10