Exendin-4-Exenatide-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Screening Libraries • Proteins www.MedChemE Exendin-4 Cat. No.: HY-13443 CAS No.: 141758-74-9 Synonyms: Exenatide 分⼦式: C₁₈₄H₂₈₂N₅₀O₆₀S 分⼦量: 4186.57 Sequence: His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Gl u-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly- Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2 Sequence Shortening: HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS- NH2 作⽤靶点: GCGR 作⽤通路: GPCR/G Protein 储存⽅式: Protect from light Powder -80°C 2 years -20°C 1 year In solvent -80°C 6 months -20°C 1 month BIOLOGICAL ACTIVITY ⽣物活性 Exendin-4 (Exenatide) 是由 39 个氨基酸组成的多肽。它是长效的 glucagon-like peptide-1 受体激动剂，IC50 值为 3.22 nM。 IC50 Target IC50: 3.22 nM (glucagon-like peptide-1 receptor) [1] 体外研究 In human umbilical vein endothelial cells, exendin-4 significantly increases NO production, endothelial NO synthase (eNOS) phosphorylation, and GTP cyclohydrolase 1 (GTPCH1) level in a dose-dependent manner [2]. Exendin-4 shows cytotoxic effects to MCF-7 breast cancer cells with IC50 of 5 μM at 48 hour [3]. 体内研究 Both low- and high-dose exendin-4 treatment in ob/ob mice improve serum ALT