抑那通治疗前列腺癌的新进展.pptxVIP

抑那通治疗前列腺癌的新进展第1页/共51页 AUA(2010)内分泌治疗新进展Radiotherapy combined with androgen deprivation vs. androgen deprivation alone in clinically locally advanced prostate caner in a multicenter randomised phase III studyNicolas Mottet, France.第2页/共51页 AUA(2010)内分泌治疗新进展INTRODUCTION AND OBJECTIVESIn locally advanced disease, the combination of radiotherapy (RT) and androgen deprivation (ADT) is superior to RT alone.But ADT with an analogue has never been compared to combined modality.We report a phase III randomised trial in locally advanced PCa, comparing a combined modality and ADT only.第3页/共51页 AUA(2010)内分泌治疗新进展METHODSIn this French multicenter, open, randomised trial, patients less than 80 years, with histologically confirmed PCa, T3-4, or pT3 (biopsy) N0M0 were included.They were centrally randomised in 2 parallel groups to either ADT alone (leuprorelin 11.25 mg SR,1 sc injection every 3 months for 3 years or the same ADT combined with RT starting within 3 months over 7 weeks.第4页/共51页 AUA(2010)内分泌治疗新进展RESULTSHTHT+RTPN131133Mean Age70.570.70.63Mean PSA baseline51.7741.500.79Median PFS (days)126425440.0005PFS (5 year) (%)15.464.70.0005Biological progression (%)71.519.50.0001Clinical progression (%)37.711.30.0001第5页/共51页 AUA(2010)内分泌治疗新进展Prevalence of metabolic syndrome in prostate cancer patients under androgen deprivation therapy: interim results of a case-control study.Jorge Ropero, Barcelone, Spain.第6页/共51页 AUA(2010)内分泌治疗新进展INTRODUCTION AND OBJECTIVESCardiovascular mortality is the most important cause of death in patients with prostate cancer (PC).The development of metabolic syndrome (MS) in patients undergoing androgen deprivation therapy (ADT) has been related with this increase in mortality rate. The aim of this study has been to confirm the hypothesis that ADT increases the prevalence of MS.第7页/共51页 AUA(2010)内分泌治疗新进展METHODSA group of 157 patients were enrolled in this interim analysis of a prospective case control study. 53 PC patients under ADT during a mean time of