药学抗感染免疫.pptxVIP

药学抗感染免疫;第一节 抗细菌感染免疫;一、细菌感染致病的机理;细菌内毒素和外毒素的性质比较;产外毒素细菌的致病机理;产内毒素细菌的致病机理;LPS引起败血性休克(septic shock);Shwartzman reaction;细菌侵入机体致病的机理;二、机体的抗菌机制;影响机体抗病力的主要因素;一些重要的抗菌物质;三、抗细菌的特异性免疫;抗产外毒素细菌感染的免疫;抗细菌感染的免疫;热休克蛋白的作用;Intracellular bacteria and their mechanisms of survival;The differential processing of live and dead bacteria;免疫反应对细菌感染的作用;四、细菌逃逸机体免疫的途径;五、机体抗细菌免疫的负面效果;六、一些抗细菌的疫苗;E coli. J5株缺O抗原;第二节 抗病毒感染免疫; 一、病毒的结构及其抗原;二、病毒感染的机理;;病毒吸附的受体; 三、机体抗病毒感染的机理;感染病毒后机体的免疫反应;四、机体抗病毒感染特异性免疫;细胞介导的抗病毒反应;;五、病毒逃逸免疫反应;病毒抗原变异;;机体产生的抗体不能中和病毒;慢病毒（lentivirus）感染;抗细菌免疫持续较短而抗病毒感染持续时间较长;六、机体抗病毒免疫的负面效果;第三节 免疫增强剂;细菌及其产物;碳水化合物;Serum HI antibody titres in the GPs immunised twice at a 3-week interval with PPV vaccines containing 1) no adjuvant, 2) GS-C, B1 (4 mg), 3) 1.5 % Al(OH)3, 4) 1.5% Al(OH)3 + GS-C, B1 (2 mg), 5) GS-C, B1 (2 mg) or 6) GS-C, B2 (2 mg) (4 GPs/group). The antibody titres were measured by HI tests two weeks after the booster injection. The bars with different letters are significantly different (P0.05). ;Serum antibody titres in the GPs immunised with PPV vaccines containing Rb1 (830 ?g), Rg1 (830 ?g) + Rg1 (830 ?g), GS-C (2 mg) or saline with a 3 weeks interval. Blood samples were taken 2 weeks after the booster for HI tests. The bars with different letters were significantly different (P0.05).;Serum IgG1 and IgG2 antibodies in GPs immunised with vaccines containing Rb1 (830 ?g ), Rg1 (830 ?g), GS-C (4 mg) or saline (5 PGs/group). Samples were taken two weeks after booster vaccination and assayed by ELISA. The results are expressed as mean ± SD of optical density (OD at 450 nm).;Mean (SD) multiples of pre-treatment serum anti-OVA antibody titres in dairy cows (n=6/group) after two injections with saline only, saline with 4 mg ovalbumin (OVA) alone or in combination with 4, 16, 64 mg ginseng extract (GS). Values with different letters differ within the time point at P0.05.;Mean (SD) optical density (OD) of serum antibodies against S. aureus in dairy heifers (n=6/group) immunized twice, at 0