NSABP乳腺癌系列临床试验.pptxVIP

NSABP乳腺癌系列临床试验第1页/共42页第2页/共42页NSABP乳腺癌系列临床试验回顾National Surgical Adjuvant Breast and Bowel Project 美国国家外科辅助乳腺癌和大肠癌研究计划 NSABP国际性合作团体，成员包括美国、加拿大、波多黎各岛、澳大利亚等近200个医学中心 到2003年止有5000多名工作人员，包括医生、护士和其他专业技术人员 已经对乳腺癌、大肠癌进行了数十个大规模随机临床试验 是第一个对乳腺癌进行大规模临床试验的组织第3页/共42页NSABP乳腺癌系列临床试验回顾 总部设在宾夕法尼亚州的匹兹堡 主席办公室和运作中心设在Allegheny医院内 生物统计中心在匹兹堡大学内 基金来源于NCI,也接受其它来源资助作为研究、培训和教育项目之用 第4页/共42页NSABP乳腺癌系列临床试验回顾B4－B35 (breast)? P1 (Preventing)P2【STAR (the study of tamoxifen and raloxifene)】 C1-c7 (colon) R1-R3 (rectum)第5页/共42页网址 / eneral NSABP Information /NSABP_Timeline.pdfMore Than 40 Years of Clinical Trial History?/Contact_NSABP.htmContact the NSABP?/NSABP_Pathology.htmPathology Section?/Future_Meetings.htmFuture Meetings?/NSABP_Newsletters.htmNSABP NewslettersClinical Trials Information?/NSABP_Protocols.htmClinical Trials Overview?/NSABP_Protocol_Chart.pdfProtocol ChartTreatment Trials Information?/B30_Information.htmProtocol B-30?/B31_Press_Info.htmProtocol B-31?/B32_Information.htmProtocol B-32?/B33_Information.htmProtocol B-33?/B34_Information.htmProtocol B-34?/B35_Information.htmProtocol B-35?/C07_Information.htmProtocol C-07Prevention Trials Information?/STAR/Index.htmlSTAR?/BCPT_Information.htmBCPT?/BreastCancerP /NSABP_Bibliography.htmBibliography of Publications/Related_Websites.htmRelated Web Sites /About_Website.htmbout the NSABP Web Site/default.aspNSABP Members Area第6页/共42页1958--- The first patient was enrolled in the first randomized clinical trial undertaken by 23 researchers from participating sites throughout the United States.1967— Dr. Bernard Fisher was appointed the chairman of the Surgical Adjuvant Chemotherapy Breast Project. No one could have foreseen the NSABP’s longevity and its impact on the treatment of breast cancer第7页/共42页1971--- Up until this time, doctors thought that breast cancer was a local disease that could only be treated with the complete removal of the breast, chest wall muscle, and underarm lymph nodes (radical mastectomy). Protocol