基于表观遗传的肿瘤免疫及其中医证本质_马萌.pdfVIP

( ) • 3503 • 中华中医药杂志原中国医药学报2020年7月第35卷第7期 CJTCMP, July 2020, Vol.35, No.7 ·思路与方法· 基于表观遗传的肿瘤免疫及其中医证本质 1,2 马　萌 1 2 （ 陕西中医药大学附属医院肿瘤科，咸阳 712000； 陕西中医药大学，咸阳 712046） 摘要：表观遗传机制既是基因组稳定性的保证，又是中医疾病证候多样化之根源，也是肿瘤中医辨证论治之 微观立足点；而肿瘤微环境是中医肿瘤辨证论治之物质基础，两者均与肿瘤细胞的免疫逃逸密切相关。肿瘤的发 生取决于表观遗传定义的肿瘤微环境免疫，表观遗传驱动的肿瘤免疫位于肿瘤形成早期，而且肿瘤微环境中可逆 的表观遗传状态支持肿瘤细胞可塑性，因此肿瘤微环境及其表观遗传机制在肿瘤发生机制中发挥了决定性作用。 表观遗传机制是联系中医证本质和肿瘤微环境之间的纽带；将表观遗传学引入中医证本质的研究，有望成为中医 现代化进程中一个较有前途的关键切入点。 关键词：表观遗传学；肿瘤免疫；中医证本质；肿瘤微环境；免疫编辑；肿瘤阴阳；免疫逃逸；免疫治疗 Tumor immunity based on epigenetics and its essence of TCM syndrome MA Meng1,2 ( 1Oncology Department, Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang 712000, China; 2Shaanxi University of Chinese Medicine, Xianyang 712046, China ) Abstract: Epigenetics is not only the guarantee of genomic stability, but also the origin of diversification of TCM syndromes in desease, and also the microcosmic standpoint of TCM syndrome differentiation and treatment in tumors; moreover, tumor microenvironment is the material basis of TCM syndrome differentiation and treatment, both of which are closely related to the immune escape and the genomic instability of tumor cells. Tumor development depends on epigenetic definition of tumor microenvironmental immunity, epigenetic-driven tumor immunity occurs in the early stages of tumor formation, and reversible epigenetic statu