抗菌药物合理使用-骨科.ppt

抗菌药物合理使用;主要内容;PK与PD;;抗菌药物的PK/PD分类;一、浓度依靠性抗菌药物（具有长PAE）;Initial serum peak level ;二、时间依靠性抗菌药物（无PAE）;Time above MIC (%);三、时间依靠性抗菌药物（具有中PAE）;Time kill curves for Pseudomonas aeruginosa ATCC 27853 with exposure to tobramycin, ciprofloxacin, and ticarcillin at concentrations from one fourth to 64 times the minimum inhibitory concentration. ( Craig WA, Ebert SC. Killing and regrowth of bacteria in vitro: A review. Scand J Infect Dis. 1991;74:63–70.) ; β-内酰胺类;注射用头孢菌素分代比较; 第三代头孢菌素抗菌谱比较（1）; 第三代头孢菌素抗菌谱比较（2）;肾功能不全个体化给药;血清肌酐与肌酐清除率;肾功能减退者不需调整剂量的抗菌药物; 抗菌药物的组织浓度;抗菌药物治疗指导原则;The association between the timing of administration of prophylaxis and the incidence of surgical site infection (SSI) following total hip arthroplasty van Kasteren,et al.Clin Infect Dis.,2007,44 (7): 921-927 ;骨科手术预防应用推举的抗菌药物;预防应用抗菌药物;;American Academy of Orthopaedic Surgeons recommended guidelines for antibiotic prophylaxis for total joint arthroplasty;抗菌药物预防应用的常见误区;抗菌药物分级管理制度;谢谢！ 抗菌药物合理使用;主要内容;PK与PD;;抗菌药物的PK/PD分类;一、浓度依靠性抗菌药物（具有长PAE）;Initial serum peak level ;二、时间依靠性抗菌药物（无PAE）;Time above MIC (%);三、时间依靠性抗菌药物（具有中PAE）;Time kill curves for Pseudomonas aeruginosa ATCC 27853 with exposure to tobramycin, ciprofloxacin, and ticarcillin at concentrations from one fourth to 64 times the minimum inhibitory concentration. ( Craig WA, Ebert SC. Killing and regrowth of bacteria in vitro: A review. Scand J Infect Dis. 1991;74:63–70.) ; β-内酰胺类;注射用头孢菌素分代比较; 第三代头孢菌素抗菌谱比较（1）; 第三代头孢菌素抗菌谱比较（2）;肾功能不全个体化给药;血清肌酐与肌酐清除率;肾功能减退者不需调整剂量的抗菌药物; 抗菌药物的组织浓度;抗菌药物治疗指导原则;The association between the timing of administration of prophylaxis and the incidence of surgical site infection (SSI) following total hip arthroplasty van Kasteren,et al.Clin Infect Dis.,2007,44 (7): 921-927 ;骨科手术预防应用推举的抗菌药物;预防应用抗菌药物;;American Academy of Orthopaedic Surgeons recommended guidelines for antibiotic prophylaxis for total joint arthroplasty;抗菌药物预防应用的常见误区;抗菌药物分级管理制度;谢谢！