VEGFR-2-IN-43-DataSheet-生命科学试剂-MCE.pdf

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Inhibitors•ScreeningLibraries•Proteins

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VEGFR-2-IN-43

Cat.No.:HY-163403

分⼦式:C₂₄H₂₇FN₄O₅

分⼦量:470.49

作⽤靶点:VEGFR

作⽤通路:ProteinTyrosineKinase/RTK

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性VEGFR-2-IN-43(compound16)是⼀种具有⼝服活性的VEGFR2抑制剂，IC50为39.91μM。VEGFR-2-IN-43

可⽤于湿性年龄相关性黄斑变性(w-AMD)疾病研究[1]。

IC50TargetVEGFR2

39.91μM(IC50)

体外研究VEGFR-2-IN-43(compound16)(0-50μM,72h)demonstratesaweakinhibitoryeffectonproliferationofLX-

2cells,andsignificantlyinhibitstheproliferationofBaF3-Tel-VEGFR2cells[1].

VEGFR-2-IN-43(0-10μM,48h)exhibitsaconcentrationdependentinhibitionofVEGFR2phosphorylationin

HUVECs[1].

VEGFR-2-IN-43(1μM,0-120min)showsremarkableplasmastabilityandmoderatelivermicrosomal

stability[1].

CellProliferationAssay[1]

CellLine:BaF3-Tel-VEGFR2cells,BaF3cells(BaF3-Tel-VEGFR2cellswereconstructedthrough

viraltransgenetechnologyusingBaF3cellsasatemplate,andtheirproliferationwas

dependentonVEGFR2kinase