Questiomycin-A-Phx-3-DataSheet-生命科学试剂-MCE.pdf

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QuestiomycinA

Cat.No.:HY-N8439

CASNo.:1916-59-2

Synonyms:Phx-3

分⼦式:C₁₂H₈N₂O₂

分⼦量:212.2

作⽤靶点:HSP;Bacterial;Antibiotic

作⽤通路:CellCycle/DNADamage;MetabolicEnzyme/Protease;Anti-

infection

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性QuestiomycinA(Phx-3)是⼀种GRP78(细胞保护性内质⽹伴侣蛋⽩)降解剂，能增强Sorafenib的抗癌活性。

QuestiomycinA也是⼀种抗菌剂/抗⽣素，可从PseudomonaschlororaphisHT66的代谢物中获得。

QuestiomycinA可⽤癌症以及植物病害⽣物防治的研究。

IC50TargetGRP78,bacterial[1][2].

体外研究QuestiomycinA(3µM;24h)inducescelldeathanddownregulatesGRP78proteinexpressioninHepG2

cells[1].

CellViabilityAssay[1]

CellLine:HepG2cells

Concentration:3µM

IncubationTime:24h

Result:Suppressedmorethan50%oftheGRP78expressionandinducedcelldeath.

体内研究QuestiomycinA(10mg/kg;i.p.;onceadayfor8days)enhancestheantitumoreffectofSorafenibby

stimulatingthedownregulationofGRP78invivo[1].

1/2Masterof