DHODH-IN-26-DataSheet-生命科学试剂-MCE.pdf

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Inhibitors•ScreeningLibraries•Proteins

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DHODH-IN-26

Cat.No.:HY-158023

分⼦式:C₄₄H₃₄BrF₂N₂O₃P

分⼦量:787.63

作⽤靶点:DihydroorotateDehydrogenase;ReactiveOxygenSpecies;

Ferroptosis

作⽤通路:MetabolicEnzyme/Protease;Immunology/Inflammation;NF-κ

B;Apoptosis

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性DHODH-IN-26(compoundB2)是⼀种靶向线粒体的DHODH抑制剂。DHODH-IN-26具有抗癌活性，可触发

活性氧(ROS)的形成，促进线粒体脂质过氧化，诱导铁死亡(ferroptosis)。

体外研究DHODH-IN-26(compoundB2)(0.01-100μM,72h)inhibitscellgrowthof4T1,B16F10,U251,GL261,SH-

SY5Y,U87,andA375cells[1].

DHODH-IN-26(50and100nM)inhibitscolonyformationinB16F10andA375cells[1].

DHODH-IN-26(50and100nM,48h)decreasestheexpressionofPD-L1inB16F10andA375cells[1].

CellViabilityAssay[1]

CellLine:4T1,B16F10,U251,GL261,SH-SY5Y,U87,andA375cells

Concentration:0.01,0.1,1,10and100μM

IncubationTime:72h

Result:Inhibitedcellgrowth.

WesternBlotAnalysis[1]

CellLine:B16F10andA375cells