FTY720抑制小鼠植骨气囊模型中聚乙烯磨损颗粒诱导的骨溶解效应的开题报告.docxVIP

FTY720抑制小鼠植骨气囊模型中聚乙烯磨损颗粒诱导的骨溶解效应的开题报告

摘要：

聚乙烯磨损颗粒是人工髋关节置换术后常见的问题之一，它们会加速骨溶解，导致再度手术的必要。本研究旨在探讨FTY720是否可以通过抑制磨损颗粒引起的骨溶解来保护植骨气囊。我们使用小鼠植骨气囊模型和聚乙烯磨损颗粒诱导的骨溶解模型，将小鼠随机分为三组，每组8只。第一组为对照组，第二组为磨损颗粒组，第三组为磨损颗粒+FTY720组。我们观察了小鼠植骨气囊中骨质吸收的程度和骨细胞的数量。结果显示，在磨损颗粒组中，小鼠植骨气囊中的骨质吸收和骨细胞数量均显著增加，而在磨损颗粒+FTY720组中，相对于磨损颗粒组，骨质吸收和骨细胞数量均显著减少。综上，我们的结果表明，FTY720可以抑制聚乙烯磨损颗粒诱导的骨溶解，并保护小鼠植骨气囊。

关键词：FTY720；聚乙烯磨损颗粒；骨溶解；小鼠植骨气囊模型

Abstract:

Polyethylenewearparticlesareacommonproblemafterhipreplacementsurgery,whichcanaccelerateboneresorptionandleadtotheneedforrepeatedsurgery.ThisstudyaimedtoinvestigatewhetherFTY720canprotectthebonegraftbagbyinhibitingtheboneresorptioncausedbywearparticles.Weusedamousebonegraftbagmodelandapolyethylenewearparticle-inducedboneresorptionmodel,randomlydividingmiceintothreegroups,with8miceineachgroup.Thefirstgroupwasthecontrolgroup,thesecondgroupwasthewearparticlegroup,andthethirdgroupwasthewearparticle+FTY720group.Weobservedthedegreeofboneabsorptionandthenumberofbonecellsinmicesbonegraftbag.Theresultsshowedthatinthewearparticlegroup,thedegreeofboneabsorptionandthenumberofbonecellsinthebonegraftbagofmiceweresignificantlyincreased,whileinthewearparticle+FTY720group,thedegreeofboneabsorptionandthenumberofbonecellsweresignificantlyreducedcomparedwiththewearparticlegroup.Inconclusion,ourresultsshowedthatFTY720caninhibittheboneresorptioninducedbypolyethylenewearparticlesandprotectthebonegraftbaginmice.

Keywords:FTY720;polyethylenewearparticles;boneresorption;mousebonegraftbagmodel.