B-blocker在慢性心力衰竭中的应用课件.pptVIP

ApplicationofbetablockersinthetreatmnetofpatientswithheartfailureClinicalseven-year06FujianPronvncialHospitalB-blocker在慢性心力衰竭中的应用

Chronicheartfailurecanimprovetheactivityofsympatheticnervoussysteminpatientswiththeextensionofdiseaseduration,itcanleadtodeteriorationofcardiovascularsystemfunction.Betablockerscaninhibittheactivityoftheneuroendocrine,thuspreventthediseaseprogression.Betablockersiswidelyusedinchronicheartfailure.PrefaceB-blocker在慢性心力衰竭中的应用

DirectoryFirst，betablockersSecond,treatmentmechanismsThird,evidence-basedFourth,guidelinesrecommendFifth，rationaluseB-blocker在慢性心力衰竭中的应用

Distributed◆Humancardiaccellshasthreebeta-blockersβ1、β2、α1◆β1andβ2receptorsinnormalhumanventricularratio:70-80/20-30%◆Heartfailure,duetoselectiveβ1receptordown,β2receptoraccountsfor35-40%B-blocker在慢性心力衰竭中的应用

1、Non-selectivebeta-twoblockersPropranolol(普奈洛尔/心得安)andPlugmelol(塞吗洛尔)Mechanism：Inhibitionofcardiac,peripheralresistanceincreases,sothatcardiacoutputdecreased2、selectivebeta-oneblockersMetoprolol（美托洛尔/倍他乐克）、Bisoprolol(比索洛尔/博苏、康忻）3、Bothα1,β1,β2blockersLabetalol(拉贝洛尔)、Carvedilol(卡维地洛/达利全、络德），Alsoknownasavasodilatoreffectofb2blockersClassificationB-blocker在慢性心力衰竭中的应用

Β-blockersusedinheartfailureBisoprololMetoprololCarvedilolB-blocker在慢性心力衰竭中的应用

MechanismfortreatmentofheartfailureB-blocker在慢性心力衰竭中的应用

--Totalnumberofpatientsmorethan20,000cases,morethan20placebo-controlledclinicalstudyhasconfirmed:ReducetheriskofdeathReduceheartfailuresymptomsToimprovethepatientsclinicalstatusImprovethegeneralconditionofthepatientReducethecombinedendpointofdeathandhospitalizationevidence-basedB-blocker在慢性心力衰竭中的应用

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