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Depression(majordepressivedisorder)山西医科大学生理学系李建国抑郁症(抑郁障碍)
Depressionisacommonmentaldisorder.Anestimated350millionpeople(5%)ofallagessufferfromdepression.Lifetimepopulationprevalenceisashighas20%.Depressionisthesecond-leadingcauseofdisability,andisamajorcontributortotheoverallglobalburdenofdisease.Morewomenareaffectedbydepressionthanmen.Atitsworst,depressioncanleadtosuicide.mentaldisorder精神障碍2
3
(PLOSmedicine,2013)depressionworldmap20104
(NationalInstituteofMentalHealth,2002)Depressionoftenco-occurswithotherillnessesCancer:25%Strokes:27%Heartattacks:33%HIV:33%ParkinsonsDisease:50%Substanceuse:27%5
61.Theneurobiologyofdepression3.Treatmentfordepression2.Diagnosticcriteriafordepression4.PreclinicalresearchDiagnosticcriteria诊断标准
7Diathesis:GeneticdiathesisEarlylifeexperience30-40%Stress:InternaleventExternaleventAmajoradverselifeeventAnaccumulationofchronicminorstresses1.TheneurobiologyofdepressionDiathesis体质
8stressIfstressisuncontrollablevPFCAMG↓Nacc↑AMG↑Nacc↓Ifstressiscontrollable1)Onsetofdepression(failuretocope)1.Theneurobiologyofdepression
9aself-sustainingviciouscircleinwhichattentiontonegativeinformationpromotesnegativethinkingadysregulatedsubcorticalnetworkandHPAaxisstress-inducedneurotoxicity.1.Theneurobiologyofdepression1)Onsetofdepression(failuretocope)2)Maintenanceofdepression(rumination)Rumination沉思viciouscircle恶性循环
10prefrontalcortex(PFC前额叶皮层)hippocampus(HYP海马)amygdala(AMG杏仁核)nucleusaccumbens(Nacc伏隔核)ventraltegmentalarea(VTA腹侧被盖区)Dorsalraphenuclei(DR/RN中缝核)hypothalamus(HP下丘脑)1.Theneurobiologyofdepression
11ventromedialprefrontalcortex(vmPFC),dorsolateralprefrontalcortex(dlPFC),hypothalamus(PVN),ant
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