ELQ-598--生命科学试剂-MCE.pdf

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ELQ-598

Cat.No.:HY-163483

CASNo.:3023709-99-8

分⼦式:C₂₈H₂₃ClF₃NO₆

分⼦量:561.93

作⽤靶点:Parasite

作⽤通路:Anti-infection

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性ELQ-598作为⼀种前体药物，它通过⼝服形式在体内转变为活性药物ELQ-596。ELQ-598显⽰出强效的寄⽣⾍

⽣长抑制能⼒(IC50=37nM)，以及对⼈类细胞的低毒性(IC50=19μM)。ELQ-598能够⽤于巴贝斯⾍病的研

究[1]。

体内研究ELQ-598(10mg/kg;p.o.;dailyDPI3-7)achievescompleteeliminationofB.duncaniinfectioninC3Hmice

[1].

ELQ-598(10mg/kg;p.o.;dailyDPI3-7)iseffectiveateliminatingB.microtiinfectioninmice[1].

ELQ-598(10mg/kg;p.o.;dailyDPI3-7)combinedwithatovaquone(HY-13832)caneliminativeofthe

infectionintheC3H/HeJmiceinfectedwithB.duncaniandSCIDmicemodelinfectedwithB.microti[1].

AnimalModel:C3HmicegeneticallypronetoB.duncaniinfection[1]

Dosage:10mg/kg

Administration:p.o.;dailyDPI3-7

Result:Resultedinacompleteeliminationoftheparasites.Micesurvivedforthedurationofthe

study