Seglitide-MK-678--生命科学试剂-MCE.pdf

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Inhibitors•ScreeningLibraries•Proteins

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Seglitide

Cat.No.:HY-106103

CASNo.:81377-02-8

Synonyms:MK-678;L-363586

分⼦式:C₄₄H₅₆N₈O₇

分⼦量:808.96

Sequence:Cyclo({Ala(Me)}-Tyr-{d-Trp}-Lys-Val-Phe)

SequenceShortening:Cyclo({Ala(Me)}-Y-{d-Trp}-KVF)

作⽤靶点:SomatostatinReceptor

作⽤通路:GPCR/GProtein;NeuronalSignaling

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Seglitide(MK-678)是⼀种有效的⽣长抑素受体2(SSTR2)激动剂，也是竞争性SSTR14、SSTR25和SSTR28拮

抗剂[1][2]。

IC50TargetSSTR2

REFERENCES

[1].DimechJ,etal.Antagonisteffectsofseglitide(MK678)atsomatostatinreceptorsinguinea-pigisolatedrightatria.BrJPharmacol.

1993;109(4):898-899.

[2].BhattaraiJP,KaszasA,ParkSA,etal.Somatostatininhibitionofgonadotropin-releasinghormoneneuronsinfemaleandmalemice[J].

Endocrinology,2010,151(7):3258-3266.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.