NOTA-COG1410--生命科学试剂-MCE.pdf

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NOTA-COG1410

Cat.No.:HY-P10220

CASNo.:2914099-35-5

分⼦式:C₇₆H₁₄₀N₂₄O₁₉

分⼦量:1694.07

Sequence:Ac-Ala-Ser-{Aib}-Leu-Arg-Lys-Leu-{Aib}-{Lys(NOTA)}-Arg-Leu-

Leu-NH2

SequenceShortening:Ac-AS-{Aib}-LRKL-{Aib}-K(NOTA)RLL-NH2

作⽤靶点:BiochemicalAssayReagents

作⽤通路:Others

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性NOTA-COG1410可以形成靶向⾻髓细胞上表达的触发受体2(TREM2)的放射性配体，通过正电⼦发射断层扫

描/计算机断层扫描，发现和诊断消化系统肿瘤[1]。

REFERENCES

[1].ShiD,etal.,SynthesisandEvaluationof68Ga-NOTA-COG1410TargetingtoTREM2ofTAMsasaSpecificPETProbeforDigestive

TumorDiagnosis.AnalChem.2022Mar8;94(9):3819-3830.

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