CDK2-IN-28--生命科学试剂-MCE.pdf

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CDK2-IN-28

Cat.No.:HY-161463

CASNo.:3025006-64-5

分⼦式:C₂₅H₃₅N₇O₃S

分⼦量:513.66

作⽤靶点:CDK

作⽤通路:CellCycle/DNADamage

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性CDK2-IN-28(compound22)是⼀种CDK2抑制机，对其他CDK具有良好选择性和细胞效应。CDK2-IN-28对

MKN1细胞具有抗增殖作⽤(EC50:0.31μM)，

IC50TargetCDK7CDK2CDK5CDK9

54.7nM(Ki,[1])1nM(Ki,[1])15.8nM(Ki,[1])12.8nM(Ki,[1])

体外研究CDK2-IN-28(37nM-3μM;24h)significantlydown-regulatesthelevelofRbphosphorylationatSer807/811

andSer780inMKN1cells[1].

CDK2-IN-28(333.3nM;24h)CDK2inhibitioninMKN1cellscausescellcyclearrestintheG2/Mphase[1].

WesternBlotAnalysis[1]

CellLine:MKN1cells

Concentration:37nM,111.1nM,333.3nM,1000nM,3000nM

IncubationTime:24h

Result:SignificantlydownregulatedRbphosphorylationatSer807/811andSer780indose

dependentway.

CellCycleAnalysis[1]