TS-24--生命科学试剂-MCE.pdf

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Inhibitors•ScreeningLibraries•Proteins

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TS-24

Cat.No.:HY-162477

CASNo.:1563260-97-8

分⼦式:C₂₀H₁₅NO₂

分⼦量:301.34

作⽤靶点:Cathepsin;Apoptosis

作⽤通路:MetabolicEnzyme/Protease;Apoptosis

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性TS-24是组织蛋⽩酶S(cathepsinS)抑制剂，IC50为4.3μM。TS-24诱导细胞凋亡(apoptosis)，在野⽣型乳

腺癌易感基因1(BRCA1)和TNBC异种移植⼩⿏模型中表现出放射增敏活性[1]。

IC50TargetcathepsinS

4.3μM(IC50)

体外研究TS-24(0-1μM,24h)inhibitsdegradationofbreastcancersusceptibilitygene1(BRCA1)incellsHEK293T,

andthusinducesradiosensitization[1].

TS-24(0-10μM,24h)inhibitscellmigrationofMDA-MB-231[1].

CellViabilityAssay[1]

CellLine:MDA-MB-231

Concentration:0-10μM

IncubationTime:24h

Result:Inhibitedcellmigration.

WesternBlotAnalysis[1]

CellLine:MDA-MB-231

Concentration:0-1μM

1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师