P-gp-inhibitor-22--生命科学试剂-MCE.pdf

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Inhibitors•ScreeningLibraries•Proteins

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P-gpinhibitor22

Cat.No.:HY-162447

CASNo.:1226674-74-3

分⼦式:C₂₀H₁₃ClN₂O₂

分⼦量:348.78

作⽤靶点:P-glycoprotein;Apoptosis

作⽤通路:MembraneTransporter/IonChannel;Apoptosis

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性P-gpinhibitor22是⼀种P-糖蛋⽩（P-gp）抑制剂，可有效抑制P-pg和外排功能。P-gpinhibitor22诱导

MCF-7/ADR细胞凋亡(apoptosis)以及S期的积累。

体外研究P-gpinhibitor22(compound4b;6.25-100μM;24h)demonstratessignificantvigouragainstMCF-7/ADR

cells[1].

P-gpinhibitor22(compound4b;5μM;24h)inducesapoptosisandaccumulationofMCF-7/ADRcells

processedintheSphase[1].

P-gpinhibitor22inhibitsavarietycelllines,suchasPC-3,SKOV-3,HeLa,MCF-7/ADR,HFL-1,andWI-38

cells,theIC50valuesof3.3 μM,0.7 μM,2.4 μM,5.0 μM,72.0 μM,and61.1 μM,respectively[1].

CellViabilityAssay[1]

CellLine:MCF-7/ADRcells

Concentration:6.25μM,12.5μM,25μM,50μM,100μM

IncubationTime:24h

Result:Showeddose-dependentcytotoxicityinMCF-7/ADRcells.