PYRIB-SO-2--生命科学试剂-MCE.pdf

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PYRIB-SO2

Cat.No.:HY-163523

分⼦式:C₁₄H₁₂ClN₃O₄S

分⼦量:353.78

作⽤靶点:Microtubule/Tubulin

作⽤通路:CellCycle/DNADamage;Cytoskeleton

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性PYRIB-SO2是⼀种有效的抗有丝分裂(mitotic)剂。PYRIB-SO2显⽰抗增殖活性并诱导细胞周期停滞在G2/M

期。PYRIB-SO2减少并破坏微管结构。PYRIB-SO2与α,β-微管蛋⽩的秋⽔仙碱结合位点(C-BS)结合[1]。

体外研究PYRIB-SO2(150nM;24h)inducescellcyclearrestatG2/Mphase[1].

PYRIB-SO2(138nM;24h)reducesanddisruptesmicrotubulestructuresinMCF7cells[1].

PYRIB-SO2(5,50µM)reducestheformationoftheEBI:β-tubulinadduct[1].

CellProliferationAssay[1]

CellLine:MCF7,MDA-MB-468,MDA-MB-231cells

Concentration:0-500nM

IncubationTime:48h

Result:ShowedantiproliferativeactivitywithIC50sof50,9,220nMforMCF7,MDA-MB-468and

MDA-MB-231cells,respectively.

CellCycleAnalysis[1]

CellLine:MCF7cells

Concentration:150nM

IncubationTime:24h

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