Rusfertide-PTG-300--生命科学试剂-MCE.pdf

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Rusfertide

Cat.No.:HY-P10272

CASNo.:1628323-80-7

Synonyms:PTG-300

分⼦式:C₁₁₄H₁₈₁N₂₇O₂₈S₂

分⼦量:2441.95

Sequence:{Asp(N-(3-methyl-1-oxobutyl))}-Thr-His-Phe-Pro-Cys-Ile-{Lys(γ

Glu-C16acid)}-Phe-Glu-Pro-Arg-Ser-Lys-Gly-Cys-Lys-NH2(di

sulfidebridge:Cys6-Cys16)

SequenceShortening:{Asp(N-(3-methyl-1-oxobutyl))}-THFPCI-{Lys(γGlu-C16acid)}-

FEPRSKGCK-NH2(disulfidebridge:Cys6-Cys16)

作⽤靶点:Ferroportin

作⽤通路:MembraneTransporter/IonChannel

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Rusfertide是天然铁调素的肽模拟物，靶向并降解ferroportin，降低⾎清铁和转铁蛋⽩饱和度，从⽽调节红细

胞的产⽣。Rusfertide可改善真性红细胞增多症、β-地中海贫⾎和遗传性⾎⾊素沉着症[1][2]。

体内研究Rusfertidelimitstheirontoxicityinredbloodcells(RBCs)(1mg/kg,s.c.,onceeverytwodays,for49days)

andtransferrin-saturation(2.5mg/kg,s.c.,onceeverytwodays,for2weeks),improvesoxygencarrying

capacityofRBCs,attenuatestheanemiaandirondepositioninmicemodelsforβ-thalassemiaand

hereditaryhemochromatosis[1].

AnimalModel:Hbbth3/+micemodelforβ-thalassemiaandhereditaryhemochr