RG7697--生命科学试剂-MCE.pdf

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Inhibitors•ScreeningLibraries•Proteins

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RG7697

Cat.No.:HY-P10271

分⼦式:C₂₁₁H₃₁₆N₄₆O₆₁

分⼦量:4473.04

Sequence:Tyr-{Aib}-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-Tyr-Leu-As

p-Lys-Gln-Ala-Ala-{Aib}-Glu-Phe-Val-Asn-Trp-Leu-Leu-Ala-Gly

-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-{Lys(C16acid)}-NH

2

SequenceShortening:Y-{Aib}-EGTFTSDYSIYLDKQAA-{Aib}-

EFVNWLLAGGPSSGAPPPS-{Lys(C16acid)}-NH2

作⽤靶点:GLPReceptor

作⽤通路:GPCR/GProtein

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性RG7697是胰⾼⾎糖素样肽受体(GLPReceptor)和葡萄糖依赖性促胰岛素多肽受体(GIPR)的双重激动剂，

EC50分别为5和3pM。RG7697具有抗⾼⾎糖活性[1]。

IC50TargetEC50:3pM(GIPR),5pM(GLPReceptor)

体内研究RG7697(3-30nmol/kg,s.c.,dailyfor7days;oronceeverytwoweeksfor30days)increasesinsulin

secretionandmetabolism,decreasesglucoseexcursion,andamelioratesdietinducedtype2diabetesand

obesityinC57BL/6micemodel[1].

AnimalModel:Dietinducedtype2diabeteandobesityinC57BL/6mice[1]

Dosage:3-30nmol/kg

Administration:s.c.,dailyfor7daysoronceeveryweekfor30days