Tat-NTS-peptide--生命科学试剂-MCE.pdf

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Inhibitors•ScreeningLibraries•Proteins

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Tat-NTSpeptide

Cat.No.:HY-P10275

分⼦式:C₁₂₅H₂₁₂N₅₄O₂₄

分⼦量:2855.37

Sequence:Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Arg-Ser-Phe-Pr

o-His-Leu-Arg-Arg-Val-Phe-NH2

SequenceShortening:YGRKKRRQRRRRSFPHLRRVF-NH2

作⽤靶点:Others

作⽤通路:Others

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Tat-NTSpeptide是细胞穿透肽，具有神经保护作⽤。Tat-NTSpeptide能特异性的抑制ANXA1的核易位，减

少缺⾎区的神经元凋亡(apoptosis)。并且Tat-NTSpeptide能减少脑缺⾎性梗死体积，可以⽤于缺⾎性卒中的

研究[1]。

体外研究Tat-NTSpeptide(20μM)blocksANXA1nuclearmigrationinneuronalcellswithoutaffectingthenuclear

translocationofotherproteins[1].

Tat-NTSpeptide(20μM)inhibitsthebindingofANXA1top53,alleviatesneuronalapoptosisinducedby

oxygenglucosedeprivation/reperfusion(OGD/R),andhasneuronalcytoprotectiveeffects[1].

Tat-NTSpeptide(20μM)cansignificantlyimprovetheviabilityofneuronalcellsafterOGD/R[1].

WesternBlotAnalysis[1]

CellLine:neuronalcells

Concentration:20μM

IncubationTime:

Result:Signific