Tat-βsyn-degron--生命科学试剂-MCE.pdf

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Tat-βsyn-degron

Cat.No.:HY-P10360

CASNo.:2816095-52-8

分⼦式:C₁₃₂H₂₃₇N₅₉O₃₁

分⼦量:3146.67

Sequence:Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Arg-Thr-Lys-Ser

-Gly-Val-Tyr-Leu-Val-Gly-Arg-Arg-Arg-Gly

SequenceShortening:YGRKKRRQRRRRTKSGVYLVGRRRG

作⽤靶点:α-synuclein

作⽤通路:NeuronalSignaling

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Tat-βsyn-degron是⼀种α-突触核蛋⽩敲低肽。Tat-βsyn-degron与α-突触核蛋⽩结合并降低原代⼤⿏⽪

质神经元培养物中的α-突触核蛋⽩⽔平。在帕⾦森⼩⿏毒性模型中，Tat-βsyn-degron还可降低α-突触核

蛋⽩⽔平并减少帕⾦森毒素诱导的神经元损伤和运动障碍。

REFERENCES

[1].JinJW,etal.Developmentofanα-synucleinknockdownpeptideandevaluationofitsefficacyinParkinsonsdiseasemodels.Commun

Biol.2021Feb19;4(1):232.

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