Boc-Leu-Gly-Arg-pNA-acetate-Boc-LGR-pNA-acetate--生命科学试剂-MCE.pdf

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Boc-Leu-Gly-Arg-pNAacetate

Cat.No.:HY-P10448

CASNo.:176786-91-7

Synonyms:Boc-LGR-pNAacetate

分⼦式:C₂₇H₄₄N₈O₉

分⼦量:624.69

Sequence:{Boc-Leu}-Gly-Arg-{pNA}

SequenceShortening:{Boc-Leu}-GR-{pNA}

作⽤靶点:Liposome

作⽤通路:MetabolicEnzyme/Protease

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Boc-Leu-Gly-Arg-pNA是⼀种能够模拟⽣物磷脂膜脂质体(liposome)。脂质体是具有同⼼磷脂双层膜囊泡的主

要成分，可以构建出⽤于抗癌和抗感染领域的药物递送系统。⾼极性的⽔溶性载荷可以被捕获在脂质体的内部

⽔性空间中，⽽亲脂性载荷可以分配到脂质双层中并成为脂质双层的⼀部分。特别是⽤于递送反义寡核苷酸

，能够克服细胞摄取低效和体内流失快等问题。

REFERENCES

[1].JulianoRL,etal.Liposomesasadrugdeliverysystemforantisenseoligonucleotides[J].Antisenseresearchanddevelopment,1992,

2(2):165-176.

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