Paliperidone-Standard--生命科学试剂-MCE.pdf

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Paliperidone(Standard)

Cat.No.:HY-A0019R

CASNo.:144598-75-4

分⼦式:C₂₃H₂₇FN₄O₃

分⼦量:426.48

作⽤靶点:DrugMetabolite;DopamineReceptor;5-HTReceptor;

AdrenergicReceptor

作⽤通路:MetabolicEnzyme/Protease;GPCR/GProtein;Neuronal

Signaling

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Paliperidone(Standard)是Paliperidone的分析标准品。本产品⽤于研究及分析应⽤。Paliperidone(9-

Hydroxyrisperidone)是Risperidone的主要活性代谢产物，是多巴胺D2(dopamineD2)拮抗剂和5-HT2A拮

抗剂。Paliperidone对α1和α2肾上腺素能受体和H1组胺能受体也有拮抗作⽤。Paliperidone是⼀种抗精

神病活性分⼦，对精神分裂症有效。

REFERENCES

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SchizophrRes.2013Jun;147(1):14-23.

[2].YangMC,etal.NeuroprotectionofpaliperidoneonSH-SY5Ycellsagainstβ-amyloidpeptide(25-35),N-methyl-4-phenylpyridiniumion,

andhydrogenperoxide-inducedcelldeath.Psychopharmacology(Berl).2011Oct;217(3):397-410.

[3].KalmanS,etal.9-hydroxy-risperidone(9OHRIS)preventsstress-inducedβ-actinoverexpressioninrathippocampus.

NeuropsychopharmacolHung.2010Sep;12(3):425-31.

[4].MauriMC,PalettaS,MaffiniM,e