5-Fluorouracil-Standard--生命科学试剂-MCE.pdf

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Inhibitors•ScreeningLibraries•Proteins

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5-Fluorouracil(Standard)

Cat.No.:HY-90006R

CASNo.:51-21-8

分⼦式:C₄H₃FN₂O₂

分⼦量:130.08

作⽤靶点:NucleosideAntimetabolite/Analog;HIV;Apoptosis;

EndogenousMetabolite

作⽤通路:CellCycle/DNADamage;Anti-infection;Apoptosis;Metabolic

Enzyme/Protease

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性5-Fluorouracil(Standard)是5-Fluorouracil的分析标准品。本产品⽤于研究及分析应⽤。5-Fluorouracil(5-

FU)是⼀种尿嘧啶的类似物(nucleosideantimetabolite/analog)，是⼀种有效的抗肿瘤药。5-Fluorouracil通

过抑制胸苷酸合成酶影响嘧啶的合成，从⽽耗尽细胞内dTTP池。5-Fluorouracil诱导细胞凋亡(apoptosis)，

可⽤作化学敏化剂。5-Fluorouracil还可抑制HIV病毒。5-Fluorouracil(5-FU)可破坏外泌体特异性的rRNA。

REFERENCES

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efficacy.JDrugTarget.2016Jun29:1-28.[Epubaheadofprint]

[2].McQuadeRM,etal.Gastrointestinaldysfunctionandentericneurotoxicityfollowingtreatmentwithanticancerchemotherapeuticagent5-

fluorouracil.NeurogastroenterolMotil.2016Jun28.

[3].ZengQ,etal.KnockdownofNFBD1/MDC1enhanceschemosensitivitytoNSC119875or5-fluorouracilinnasopharyngealcarcinoma

CNE1cells.MolC