Ondansetron-Standard--生命科学试剂-MCE.pdf

Hotline:400-820-3792

Inhibitors•ScreeningLibraries•Proteins

www.MedChemE

Ondansetron(Standard)

Cat.No.:HY-B0002BR

CASNo.:99614-02-5

分⼦式:C₁₈H₁₉N₃O

分⼦量:293.36

作⽤靶点:5-HTReceptor

作⽤通路:GPCR/GProtein;NeuronalSignaling

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Ondansetron(Standard)是Ondansetron的分析标准品。本产品⽤于研究及分析应⽤。Ondansetron(GR

38032;SN307)为⼀种⾼度选择性的5-HT3受体拮抗剂，IC50值为103pM。Ondansetron通过拮抗位于周围

和中枢神经局部的神经原的5-HTreceptor⽽发挥⽌吐作⽤。Ondansetron能抑制由化疗和放疗引起的恶⼼呕

吐。Ondansetron有⼝服⽣物活性[1][2][3][4][5][6][7][8]。

REFERENCES

[1].BrownAM,etal.Ionpermeationandconductioninahumanrecombinant5-HT3receptorsubunit(h5-HT3A).JPhysiol.1998Mar

15;507(Pt3):653-65.

[2].BarannM,etal.Recombinanthuman5-HT3Areceptorsinoutside-outpatchesofHEK293cells:basicpropertiesandbarbiturate

effects.NaunynSchmiedebergsArchPharmacol.2000Sep;362(3):255-65.

[3].WildeboerKM,etal.OndansetronresultsinimprovedauditorygatinginDBA/2micethroughacholinergicmechanism.BrainRes.2009

Dec1;1300:41-50.

[4].KhedhaierA,etal.Circadianrhythmsintoxiceffectsoftheserotoninantagonistondansetroninmice.ChronobiolInt.2003

Nov;20(6):1103-16.

[5].UmatheSN,etal.The5-HT3receptorantagonist,ondansetron