AGI-14100--生命科学试剂-MCE.pdf

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Inhibitors•ScreeningLibraries•Proteins

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AGI-14100

Cat.No.:HY-120181

CASNo.:1448346-43-7

分⼦式:C₂₉H₂₂ClF₄N₅O₃

分⼦量:599.96

作⽤靶点:IsocitrateDehydrogenase(IDH)

作⽤通路:MetabolicEnzyme/Protease

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性AGI-14100是⼀种代谢稳定性好且可⼝服的mIDH1抑制剂(IC50=6nM)。AGI-14100的医药化学优化旨在消

除hPXR激活，从⽽得到最终的候选药物AG-120。AG-120可⽤于对携带IDH1突变癌症的研究。AGI-14100

的发现和开发可⽤于mIDH1抑制剂的深⼊研究[1]。

IC50TargetmIDH

6nM(IC50)

REFERENCES

[1].Popovici-MullerJ,etal.DiscoveryofAG-120(Ivosidenib):afirst-in-classmutantIDH1inhibitorforthetreatmentofIDH1mutant

cancers[J].ACSmedicinalchemistryletters,2018,9(4):300-305.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

Forresearchuseonly.

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