Bazedoxifene-Standard--生命科学试剂-MCE.pdf

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Bazedoxifene(Standard)

Cat.No.:HY-A0031R

CASNo.:198481-32-2

分⼦式:C₃₀H₃₄N₂O₃

分⼦量:470.6

作⽤靶点:EstrogenReceptor/ERR

作⽤通路:VitaminDRelated/NuclearReceptor

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Bazedoxifene(Standard)是Bazedoxifene的分析标准品。本产品⽤于研究及分析应⽤。Bazedoxifene(TSE-

424)是⼀种有⼝服活性的，能透过⾎脑屏障的，⾮甾体、选择性的雌激素受体调节剂(SERM)，对ERα和ER

β作⽤的IC50值分别为26nM和99nM，可⽤于⾻质疏松症的研究。Bazedoxifene也是⼀种IL-6/GP130蛋

⽩相互作⽤抑制剂，可⽤于胰腺癌的研究[1][2]。

IC50TargetIC50:26nM(ERα),99nM(ERβ)[1]

REFERENCES

[1].BarrySKomm,etal.Bazedoxifeneacetate:aselectiveestrogenreceptormodulatorwithimprovedselectivity.Endocrinology.2005

Sep;146(9):3999-4008.

[2].XiaojuanWu,etal.BazedoxifeneasaNovelGP130InhibitorforPancreaticCancerTherapy.MolCancerTher.2016Nov;15(11):

2609–2619.

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Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

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