CaMKI-299-320-Calmodulin-Dependent-Protein-Kinase-I-299-320-Binding-Domain--生命科学试剂-MCE.pdf

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Inhibitors•ScreeningLibraries•Proteins

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CaMKI(299-320)

Cat.No.:HY-P10316

CASNo.:205598-38-5

Synonyms:Calmodulin-DependentProteinKinaseI(299-320)Binding

Domain

分⼦式:C₁₁₆H₁₉₂N₃₈O₂₈S

分⼦量:2599.07

Sequence:Ala-Lys-Ser-Lys-Trp-Lys-Gln-Ala-Phe-Asn-Ala-Thr-Ala-Val-Val

-Arg-His-Met-Arg-Lys-Leu-Gln

SequenceShortening:AKSKWKQAFNATAVVRHMRKLQ

作⽤靶点:CaMK

作⽤通路:NeuronalSignaling

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性CaMKI(299-320)是指钙/钙调蛋⽩依赖性蛋⽩激酶I(Calcium/calmodulin-dependentproteinkinaseI，简称

CaMKI)的第299⾄320位氨基酸残基组成的肽段。CaMKI(299-320)作为蛋⽩激酶，与Ca2+–CaM具有⾼亲

和⼒(Kd≤1nM)，能够磷酸化特定的底物蛋⽩，从⽽调节它们的活性。CaMKI(299-320)包含了CaM结合域

和⾃我抑制域，CaMKI(299-320)可⽤于细胞⽣理过程的研究，包括细胞增殖，分化和凋亡[1]。

REFERENCES

[1].YuanT,etal.Spectroscopiccharacterizationofthecalmodulin-bindingandautoinhibitorydomainsofcalcium/calmodulin-dependent

proteinkinaseI[J].Archivesofbiochemistryandbiophysics,2004,421(2):192-206.

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