病原体真菌学青岛医学院微生物中心目标mycology2013.pptx

病原体真菌学青岛医学院微生物中心目标mycology2013.pptx

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1FungalPathogens:

Mycology

WeiZhao,Ph.D.MedicalMicrobiologyCenterCollegeofMedicalSciencesQingdaoUniversity

2Objectives:Abasicunderstandingoffungiandthediseasestheycause.List4characteristicsoffungi.Definemajorcategoriesofmycosis.Dimorphicfungiandpathogenesis.EIDandopportunisticfungi.

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4IntroductiontoMycologyBeer,Wine,BreadVinegar,CheeseGourmetmushroomsAntibioticsBiodegradationDiseaseOftheapproximately70,000recognizedspeciesoffungi,about300areknowntocausehumaninfections.Ringworminfectiononleg

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9MajorCategoriesofFungalInfectionInfection:passtheresistancebarriersofthehumanbody.classifiedaccordingtothetissuelevelsinitiallycolonizedSuperficial:limitedtotheoutermostlayersoftheskinandhair.Cutaneous:extenddeeperintotheepidermis,aswellasinvasivehairandnaildiseases.Subcutaneous–Lymphatic:involvingthedermis,subcutaneoustissues,muscleandfascia

10MajorSpeciesCauseFungalInfectionSuperficial:Malasseziafurfur,Tineaversicolor;TineaCutaneous:Trichophyton,Epidermophyton,Microsporum(Tinea-causingdermatophytes)Candidaalbicans(thrushdiaperrash)Subcutaneous-Lymphatic:Sporothrixschenckii(Sporotrichosis,Rosegrowersdisease”),Chromoblastomycosis

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26Sporothrixschenckiihasayeastformat37°C.

YoungcoloniesofSporothrixschenckiiremainwhiteforsometimeat25°C.

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29SystemicMycosesInvolveskinanddeepvisceraMayewidelydisseminatedPredilectionforspecificorgans

30EndemicMycosesGeographicallyrestrictedtospecificareasofendemicity.Coccidioidesspp.andHistoplasmaspp.exitindrysoil;thehabitsofBlastomycesspp.andParacoccidioidesspp.havenotbeenclearlydefined.Infectionsinitiateinthelungs,afewleadtodisease,mayinvolvedisseminationtootherorgans.Nottransmissibleamonghumans(animals).Dimorphicfungi.

31DimorphicFungiYeastFormParasiticformTissuefo

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