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MetastaticCancerUnknownPrimarySite1大家好
MetastaticCancer
UnknownPrimarySite
Synonymsandrelatedkeywords◆tumorofunknownprimary◆cancerofunknownorigin◆carcinomaofunknownorigin◆unknownprimarycancer2大家好
MetastaticCancer
UnknownPrimarySite
◆unknownprimarycarcinoma◆carcinomaofunknownprimaryorigin3大家好
MetastaticCancer
UnknownPrimarySite
◆cancerofunknownprimarysite(cups)◆carcinomaofunknownprimaryorigin(CUP)4大家好
MetastaticCancer
UnknownPrimarySite
◆metastaticcancer◆metastaticcarcinoma◆metastatictumor◆metastases◆occultprimarymalignancy5大家好
CUP
Background(intheUnitedStates)◆32,100patswithCUPSin2007(15,720males;16,380females)◆About2%ofallcancers6大家好
CUP
◆DeathsduetoCUPS:45,230(24,440males;20,790females)7大家好
CUP◆Thisdiscrepancybetweenincidenceandmortalityisbelievedtobeduetoalackofspecificityinthelistingof?causeofdeathondeathcertificates8大家好
CUP
◆Itstrueincidenceismostprobablybetween2%and6%◆In15-25%ofcases,theprimarysitecannotbeidentifiedevenonpostmortem9大家好
CUP
Pathophysiology◆Cancersarethoughttoarisefromasinglecellthatescapesthecontrolsofnormalcellreplication◆Formsatumoratthesiteoforigin◆Ultimatelymetastasizestootherorgans10大家好
CUP
Pathophysiology◆Insomecasestheoriginaltumormayremainsmallorundetectableatthetimeofmetastasis◆LeadingtotheclinicalpresentationofCUP11大家好
CUPFrequency◆UnitedStates:2-6%?◆International:2-9%12大家好
CUPMortality/Morbidity◆Mediansurvival?rangesfrom11weeksto11months◆The5-yearoverallsurvivalrateisabout11%13大家好
CUPSex◆Anapproximateequalincidenceformenandwomen14大家好
CUP
Age◆Themedianageonpresentationforbothmenandwomenrangesfrom59-66years15大家好
CUP
CLINICAL(History)◆Becausemostpatientswithcuphave
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