接受前列腺癌根治术和随后短期辅助雄激素剥夺治疗的临床局限性前列腺癌患者的睾酮恢复动力学.pdfVIP

AsianJournalofAndrology(2013)15．466-470

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ORIGINALARTICLE

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KineticsofteSt0Ster0nerecoveryinclinicallylocalized

tecancerpatientstreatedwithradicaI

pros

prostectomyandsubsequentshort--termadjuvant

-

androgendeprivationtherapy

BoDai，，，Yuan．YuanQu，，，Yun—YiKong2’，Ding—WeiYe’，Xu—DongYao，Shi—LinZhang，

Hai—LiangZhang，andWei—YiYang’

Androgendeprivationtherapy(ADT)isastandardtreatmentformetastatic．recurrentandlocallyadvancedprostatecancer(Pea)．The

aimofthisstudyistoinvestigatethetimingandextentoftestosteronerecoveryinclinicallylocalizedPeapatientstreatedwithradical

prostatectomy(RP)andsubsequentshort．termadjuvantADT．Atotalof95IocalizedPCapatientsunderwentRPand9-monthadjuvant

ADTwereincludedinthisprospectivestudy．SerumtestosteroneIeve1wasmeasuredbeforeadjuvantADT，atADTcessation，andat1，

3．6．9and12monthsaftercessationofADT．ACoxproportionalhazardsmodelwasusedtoassessvariablesassociatedwiththetimeof

testosteronenormalization．Theresultsshowedthatmedianpatientagewas67yearsandmediantestosteroneleveIbeforeadjuvant

ADTwas361(230—905)ngdl一1．AIlpatientsfinished9．monthadjuvantADTandachievedcastratetestosteroneleve1．At3months

afterADTcessation．testosteronerecoveredtosupracastrateleveIin97．9％patientsandtonormalleveIin36．9％patients．The

percentageofpatientswhorecoveredtonormaltestosteronelevelincreasedto66．3％．86．3％and92．6％at6，9and12months，

respectively．CoxregressionmodelfoundthathigherbaselinetestosteroneIeveI(≥300ngdI一)wastheonlyvariableassociatedwitha

shortertimetotestosteronenormalization(hazardratio：1．98；P=0．012)．Inconclusion，inmostpatients，testosteronerecoveredto

supracastratelevelat3monthsandtonormaIlevelat12monthsafter9-monthadjuvantADTcessation．Patientswithhigherbaseline

testosteroneleveIne