AC-VEID-CHO-生命科学试剂-MCE.pdf

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AC-VEID-CHO

Cat.No.:HY-108312

CASNo.:319494-39-8

分⼦式:C₂₂H₃₆N₄O₉

分⼦量:500.54

作⽤靶点:Caspase

作⽤通路:Apoptosis

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性AC-VEID-CHO是⼀种多肽来源的半胱天冬酶抑制剂，对Caspase-6、Caspase-3和Caspase-7具有抑制作⽤，

IC50值分别为16.2nM、13.6nM和162.1nM。AC-VEID-CHO还抑制VEIDase活性，IC50值为0.49µM。AC-

VEID-CHO可被⽤于阿尔茨海默病、亨廷顿病等神经退⾏性疾病的研究。

IC50TargetCaspase3Caspase-6Caspase-7

13.6nM(IC50)16.2nM(IC50)162.1nM(IC50)

REFERENCES

[1].RobertMintzer,etal.Awholecellassaytomeasurecaspase-6activitybydetectingcleavageoflaminA/C.PLoSOne.

2012;7(1):e30376.

McePdfHeight

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