DC371739-生命科学试剂-MCE.pdf

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Inhibitors•ScreeningLibraries•Proteins

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DC371739

Cat.No.:HY-163794

CASNo.:2135765-21-6

分⼦式:C₂₉H₃₀N₂O₄

分⼦量:470.56

作⽤靶点:ANGPTL;PCSK9

作⽤通路:MetabolicEnzyme/Protease

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性DC371739是⼀种有效的，具有⼝服活性的PCSK9抑制剂。DC371739可降低PCSK9和ANGPTL3的mRNA

表达。DC371739可降低PCSK9的蛋⽩表达并增加LDLR的蛋⽩表达。DC371739具有⽤于⾼脂⾎症研究的潜

⼒[1][2]。

体外研究DC371739(0-10µM,0-24h)increasestheratioofDiI-LDLuptakeinadose-andtime-dependentmannerin

HepG2cells[2].

DC371739(0-5µM;4,24,48h)decreasesthemRNAexpressionofPCSK9andANGPTL3inHepG2cells

[2].

DC371739(0-10µM;24h)decreasestheproteinexpressionofPCSK9andincreasestheproteinexpression

ofLDLR[2].

DC371739(5µM;24h)inhibitsANGPTL3transcriptionandexpressionbytargetingHNF-1α[2].

RT-PCR[2]

CellLine:HepG2cells

Concentration:0-5µM

IncubationTime:4,24,48h

Result:DecreasedthemRNAexpressionofPCSK9andANGPTL3inadoseandtime