GLUT1-EGFR-IN-1-生命科学试剂-MCE.pdf

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Inhibitors•ScreeningLibraries•Proteins

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GLUT1/EGFR-IN-1

Cat.No.:HY-163726

CASNo.:2393787-80-7

分⼦式:C₄₄H₃₂N₄O₅

分⼦量:696.75

作⽤靶点:GLUT;EGFR;Apoptosis

作⽤通路:MembraneTransporter/IonChannel;JAK/STATSignaling;

ProteinTyrosineKinase/RTK;Apoptosis

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性GLUT1/EGFR-IN-1(compoundH)是GLUT1和EGFR的强效抑制剂。GLUT1/EGFR-IN-1可同时作⽤于EGFR酪

氨酸激酶ATP结合位点并抑制GLUT1介导的能量代谢，导致ATP、MMP、细胞内乳酸和EGFR核转移减少。

GLUT1/EGFR-IN-1可⽤于⿐咽癌(NPC)和三阴性乳腺癌(TNBC)研究。

IC50TargetGLUT1EGFR

体外研究GLUT1/EGFR-IN-1(compoundH)showedoutstandingantitumouractivityinCNE1andMDA-MB231cells,

withIC50valueslowerthan3µmol/L,butactivitywasnotobviousinCNE2cells[1].

GLUT1/EGFR-IN-1(0-4μM,48h)inhibitstheexpressionofEGFRandp-EGFRinbothCNE1andMDA-

MB231cells[1].

GLUT1/EGFR-IN-1(0-4μM,48h)inducesapoptosisinCNE1andMDA-MB231cells[1].

WesternBlotAnalysis[1]

CellLine:CNE1andMDA-MB231cells

Concentration:1μmol/L,2,4μmol/L

IncubationTime