Olomoucine-II-生命科学试剂-MCE.pdf

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OlomoucineII

Cat.No.:HY-112450

CASNo.:500735-47-7

分⼦式:C₁₉H₂₆N₆O₂

分⼦量:370.45

作⽤靶点:CDK

作⽤通路:CellCycle/DNADamage

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性OlomoucineII是⼀种有效的CDK抑制剂，对CDK9/cyclinT,CDK2/cyclinE,CDK7/cyclinH,CDK1/cyclinB,

CDK4/cyclinD1的IC50值分别为0.06、0.1、0.45、7.6和19.8µM。OlomoucineII具有抗增殖活性[1]。

IC50TargetCDK9/cycTCDK2/cyclinECDK7/cyclinHCdk1/cyclinB

0.06μM(IC50)0.1μM(IC50)0.45μM(IC50)7.6μM(IC50)

CDK4/cyclinD1

19.8μM(IC50)

体外研究OlomoucineII(72h)showsantiproliferativeactivitywithIC50sof9.3,9.2,10.5,13.6,5.0,10.8,5.3,2.7,16.3

µMforHOS,T98G,HBL100,BT474,MCF-7,HT-29,CCRF-CEM,BV173,HL60cells,respectively[1].

CellProliferationAssay[1]

CellLine:HOS,T98G,HBL100,BT474,MCF-7,HT-29,CCRF-CEM,BV173,HL60cells

Concentration:

IncubationTime:72h

Result:ShowedantiproliferativeactivitywithIC50sof